In Paraguay, for the past three years the Ministry of Education and Culture and the IDB have jointly studied what works in math and science education in Paraguay. During this time we have been fortunate to develop meaningful partnerships with hundreds of school districts, as well as with the Japan International Cooperation Agency and the Organization of Ibero-American States. With this publication we hope to invite other actors from the private and nongovernmental sectors and from the donor community to partner with us in promoting math and science learning for all Paraguayan children.