When implementing hospital infrastructure projects, there are various management modalities and implementation strategies. These modalities may include the independent contracting of design, construction, and equipment (traditional), or a combination of any of these; an in-house or external management scheme; a designer and manager scheme; a design and construction or construction and equipment scheme; the "turnkey" modality; or a Public-Private Partnership (PPP) scheme, which includes infrastructure operation and maintenance for a specified period of time. Based on the analysis of 15 real cases of projects implemented in Latin America and the Caribbean (LAC), this document analyzes the different modalities used with the goal of obtaining lessons learned and recommendations to improve project implementation practices. The analysis covers aspects related to project governance, as well as scope, timeframes, and costs, in accordance with the different implementation modalities.