The COVID-19 pandemic has revealed the inadequacies of outdated paper-based vaccine certification methods and health information systems, emphasizing the urgent need for digital transformation in managing immunization records. The Pan American Health Organization (PAHO) aims to enhance health systems through innovative technologies, promoting secure digital vaccination certificates that improve accessibility and verifiability. PAHO's initiative, supported by Member States, seeks to build resilient health systems across the Americas, ensuring equitable access and improved health outcomes. The roadmap for this transformation outlines strategic actions to create a more connected and efficient health sector capable of addressing modern public health challenges.